Antibiotic resistance has been selected as the focus for a £10m prize that will aim to tackle one of the world's biggest challenges.
Six themes were originally identified by the organisers; the public was then invited to vote for their choice.
The competition is based on the 1714 Longitude Prize won by John Harrison.
Harrison's clock allowed sailors to pinpoint their position at sea for the first time.
The outcome of the public vote was announced on the BBC's One Show on Wednesday.
The charity Nesta and the government-funded Technology Strategy Board have offered the £10m for the prize.